Levodopa failure in chronic manganism

@article{Lu1994LevodopaFI,
  title={Levodopa failure in chronic manganism},
  author={C. S. Lu and C. C. Huang and N. Chu and D. Calne},
  journal={Neurology},
  year={1994},
  volume={44},
  pages={1600 - 1600}
}
We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over a period of 5 years after they left the site of exposure. Initially the patients appeared to respond to levodopa in open observations, but this apparent benefit was not sustained. This short-term, double-blind study indicates that their parkinsonism and dystonia failed to respond to levodopa. 
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