Levodopa enhances synaptic plasticity in the substantia nigra pars reticulata of Parkinson's disease patients.

@article{Prescott2009LevodopaES,
  title={Levodopa enhances synaptic plasticity in the substantia nigra pars reticulata of Parkinson's disease patients.},
  author={Ian A. Prescott and Jonathan O. Dostrovsky and Enrico Moro and Mojgan Hodaie and Andres M. Lozano and William Duncan Hutchison},
  journal={Brain : a journal of neurology},
  year={2009},
  volume={132 Pt 2},
  pages={
          309-18
        }
}
Parkinson's disease, caused by the loss of dopaminergic nigrostriatal projections, is a debilitating neurodegenerative disease characterized by bradykinesia, rigidity, tremor and postural instability. The dopamine precursor levodopa (L-dopa) is the most effective treatment for the amelioration of Parkinson's disease signs and symptoms, but long-term administration can lead to disabling motor fluctuations and L-dopa -induced dyskinesias (LIDs). Studies in rat striatal slices have shown dopamine… CONTINUE READING

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