Levodopa: A Review of its Pharmacological Properties and Therapeutic Uses with Particular Reference to Parkinsonism

@article{Brogden1971LevodopaAR,
  title={Levodopa: A Review of its Pharmacological Properties and Therapeutic Uses with Particular Reference to Parkinsonism},
  author={Rex N. Brogden and T. M. Speight and G. S. Avery},
  journal={Drugs},
  year={1971},
  volume={2},
  pages={262-400}
}
Synopsis: Levodopa2 is the laevo optical stereoisomer of the L-configurational form of dopa [L-(−)-dopa] and is advocated for the symptomatic treatment of Parkinson’s syndrome. It is probably of no practical value in drug-induced Parkinsonism. Unlike dopamine, levodopa crosses the blood-brain barrier and is converted to dopamine by the enzyme dopa decarboxylase. As the activity of this enzyme is greater in the periphery (eg. liver, kidneys, heart) than in the brain, much of the administered… CONTINUE READING