Levodopa/carbidopa microtablets in Parkinson’s disease: a study of pharmacokinetics and blinded motor assessment

@inproceedings{Senek2017LevodopacarbidopaMI,
  title={Levodopa/carbidopa microtablets in Parkinson’s disease: a study of pharmacokinetics and blinded motor assessment},
  author={Marina Senek and S. -M. Aquilonius and H{\aa}kan Askmark and Filip Bergquist and Radu Constantinescu and Anders Ericsson and Sara Lycke and Alexander V. Medvedev and Mevludin Memedi and Fredrik Ohlsson and Jack Spira and Jerker Westin and Dag Nyholm},
  booktitle={European Journal of Clinical Pharmacology},
  year={2017}
}
Motor function assessments with rating scales in relation to the pharmacokinetics of levodopa may increase the understanding of how to individualize and fine-tune treatments. This study aimed to investigate the pharmacokinetic profiles of levodopa-carbidopa and the motor function following a single-dose microtablet administration in Parkinson’s disease. This was a single-center, open-label, single-dose study in 19 patients experiencing motor fluctuations. Patients received 150% of their… CONTINUE READING