Levobupivacaine caudal anesthesia in children: a randomized double-blind comparison with bupivacaine.

@article{Frawley2006LevobupivacaineCA,
  title={Levobupivacaine caudal anesthesia in children: a randomized double-blind comparison with bupivacaine.},
  author={Geoff P Frawley and Sarah Downie and Grace H. Huang},
  journal={Paediatric anaesthesia},
  year={2006},
  volume={16 7},
  pages={
          754-60
        }
}
BACKGROUND Levobupivacaine is the pure S-enantiomer of bupivacaine. Despite obvious benefits in the event of accidental intravascular injection there has been no studies demonstrating a clinically significant benefit to levobupivacaine over racemic bupivacaine for pediatric regional anesthesia. Given the similar pharmacokinetic profiles of both drugs the studies to date have been underpowered to demonstrate what is likely to be a small difference in clinical effectiveness. Our aim was to… CONTINUE READING

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References

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SHOWING 1-10 OF 42 REFERENCES

Caudal anaesthesia for minor pediatric surgery : a prospective randomized comparison of ropivacaine 0 . 2 % vs . levobupivacaine 0 . 2 %

G Ivani, P DeNegri, Lonnqvist P-A
  • Pediatr Anesth
  • 2005

Efficacy and safety

R Taylor, R Eyres, GA Chalkiadis
  • blockade. Pediatr Anesth
  • 2005

Motor blockade potency and toxicity of non racemic bupivacaine in rats

MM Trachez, G Zapato-Sudo, OR Moreira
  • Acta Anaesthesiol Scand
  • 2005

caudal route in children

G Ivani, P DeNegri, P-A Lonnqvist
  • Br J Anaesth
  • 2005

A comparison of epidural bupivacaine , levobupivacaine and ropivacaine on postoperative analgesia and motor blockade

P DeNegri, G Ivani, T Tirri
  • Anesth Analg
  • 2004