Levobupivacaine: a review of its pharmacology and use as a local anaesthetic.

  title={Levobupivacaine: a review of its pharmacology and use as a local anaesthetic.},
  author={Rachel H. Foster and Anthony Markham},
  volume={59 3},
UNLABELLED Based on findings that the cardiotoxicity infrequently observed with racemic bupivacaine shows enantioselectivity, i.e. it is more pronounced with the R(+)-enantiomer, the S(-)-enantiomer (levobupivacaine) has been developed for clinical use as a long acting local anaesthetic. The majority of in vitro, in vivo and human pharmacodynamic studies of nerve block indicate that levobupivacaine has similar potency to bupivacaine. However, levobupivacaine had a lower risk of cardiovascular… CONTINUE READING
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Comparative effect of racemic bupivacaine , levobupivacaine and ropivacaine on isolated rabbit heart [ abstract ]

  • JX Mazoit, J Decaux, H Bouaziz
  • Anesthesiology
  • 1999

Comparative systemic toxicity of levobupivacaine , bupivacaine and ropivacaine during ovine pregnancy [ abstract ]

  • AC Santos
  • Anesth Analg
  • 1999

Comparison of 0 . 125 % levobupivacaine and 0 . 125 % bupivacaine epidural infusions for labour analgesia [ abstract ]

  • P Convery, D Burke, L Donaldson
  • Br J Anaesth
  • 1999

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