Levobupivacaine: a review of its pharmacology and use as a local anaesthetic.

@article{Foster2000LevobupivacaineAR,
  title={Levobupivacaine: a review of its pharmacology and use as a local anaesthetic.},
  author={Rachel H. Foster and Anthony Markham},
  journal={Drugs},
  year={2000},
  volume={59 3},
  pages={551-79}
}
UNLABELLED Based on findings that the cardiotoxicity infrequently observed with racemic bupivacaine shows enantioselectivity, i.e. it is more pronounced with the R(+)-enantiomer, the S(-)-enantiomer (levobupivacaine) has been developed for clinical use as a long acting local anaesthetic. The majority of in vitro, in vivo and human pharmacodynamic studies of nerve block indicate that levobupivacaine has similar potency to bupivacaine. However, levobupivacaine had a lower risk of cardiovascular… CONTINUE READING
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