Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats

@article{Mantsch2007LevotetrahydropalmatineAC,
  title={Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats},
  author={John R Mantsch and Shi-Jiang Li and Robert Risinger and Sarah Awad and Eric S. Katz and David A. Baker and Zheng Yang},
  journal={Psychopharmacology},
  year={2007},
  volume={192},
  pages={581-591}
}
RationaleLevo-tetrahydropalmatine (l-THP) is an alkaloid constituent of plants from the botanical genera Corydalis and Stephania and is contained in many traditional Chinese herbal preparations. In addition to its low-affinity antagonism of D2 dopamine (DA) receptors, we report that l-THP functions as a higher-affinity antagonist at D1 DA receptors and interacts with D3 DA receptors, suggesting that it may be effective for the treatment of drug addiction. Accordingly, l-THP has been reported to… 
l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats
TLDR
Since l-THP reduces nicotine taking and blocks relapse it could be a useful alternative to varenicline and bupropion as a treatment for nicotine addiction.
Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse
TLDR
The combination of l-THP and LDN has great potential as an effective and well-tolerated medication for cocaine relapse prevention, and treatment with the combination has an upregulatory effect on both plasma β-endorphin and hypothalamic POMC that was not observed in l- THP-treated groups.
l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction.
TLDR
The results of preclinical work demonstrating that l-THP attenuates cocaine's reinforcing/rewarding effects and reinstatement in rat models of cocaine relapse are summarized, and the outcomes of studies demonstrating efficacy in human addicts are described.
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