Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses.

@article{Moore2010LevetiracetamPI,
  title={Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses.},
  author={S A Moore and Karen R Mu{\~n}ana and Mark G Papich and Julie A Nettifee-Osborne},
  journal={American journal of veterinary research},
  year={2010},
  volume={71 3},
  pages={337-41}
}
OBJECTIVE To measure pharmacokinetics of levetiracetam (LEV) after single-dose oral administration in healthy dogs and determine whether pharmacokinetics changed after repeated oral dosing. ANIMALS 6 healthy adult dogs. PROCEDURES Pharmacokinetics were calculated following administration of a single dose (mean, 21.7 mg/kg, PO; day 1) and after administration of the last dose following administration for 6 days (20.8 to 22.7 mg/kg, PO, q 8 h; days 2 to 7). Plasma LEV concentrations were… CONTINUE READING
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