Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.

@article{Tomi2013LevetiracetamIS,
  title={Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.},
  author={Maja A Tomi{\'c} and Ana M Micov and Radica M Stepanovi{\'c}-Petrovi{\'c}},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2013},
  volume={14 11},
  pages={1371-82}
}
UNLABELLED Levetiracetam is a novel anticonvulsant with antihyperalgesic efficacy in inflammatory pain. Nonsteroidal analgesics and caffeine, as analgesic adjuvant, are widely used against inflammatory pain. This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress… CONTINUE READING