Levetiracetam accumulation in renal failure causing myoclonic encephalopathy with triphasic waves

@article{Vulliemoz2009LevetiracetamAI,
  title={Levetiracetam accumulation in renal failure causing myoclonic encephalopathy with triphasic waves},
  author={Serge Vulliemoz and Patricia Iwanowski and Theodor Landis and Pierre Jallon},
  journal={Seizure},
  year={2009},
  volume={18},
  pages={376-378}
}
Triphasic waves are seen in the electro-encephalogram of adult patients with toxic-metabolic encephalopathies of various origins. Levetiracetam is a broad spectrum anti-epileptic drug with renal elimination and no hepatic metabolism. We describe the case of encephalopathy with triphasic waves concomitant with levetiracetam accumulation in a patient with chronic renal failure. The condition was reversible after down-titration of levetiracetam with no change of the renal function. Other causes of… CONTINUE READING

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