Leveraging single protein polymers to measure flexural rigidity.

  title={Leveraging single protein polymers to measure flexural rigidity.},
  author={Joost van Mameren and Karen C. Vermeulen and Fred Gittes and Christoph F Schmidt},
  journal={The journal of physical chemistry. B},
  volume={113 12},
The micrometer-scale length of some protein polymers allows them to be mechanically manipulated in single-molecule experiments. This provides a direct way to measure persistence length. We have used a double optical trap to elastically deform single microtubules and actin filaments. Axial extensional force was exerted on beads attached laterally to the filaments. Because the attachments are off the line of force, pulling the beads apart couples to local bending of the filament. We present a… CONTINUE READING

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