Leveraging growth factor induced macropinocytosis for targeted treatment of lung cancer.

  title={Leveraging growth factor induced macropinocytosis for targeted treatment of lung cancer.},
  author={Raul Iglesias and Piyush Koria},
  journal={Medical oncology},
  volume={32 12},
Targeted therapy focused on highly expressed growth factor receptors is increasingly becoming popular for the treatment of lung cancer. Cancer cells exhibit higher levels of macropinocytosis than the normally quiescent non-cancerous cells, which can further be enhanced by growth factors. Here, we show the targeted enhancement of macropinocytosis in lung cancer cells for the delivery of the mitochondriotoxic peptide (KLAKLAK)2 using keratinocyte growth factor (KGF). We report the formation of a… CONTINUE READING
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