Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state.

@article{Guerreiro2006LevelsOS,
  title={Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state.},
  author={Jaqueline B Guerreiro and Silvane Maria Braga Santos and Daniel J Morgan and Aur{\'e}lia Fonseca Porto and Andr{\'e} L. N. Muniz and John K. L. Ho and Ana L. Teixeira and Mauro M Teixeira and Edgar Marcelino de Carvalho},
  journal={Clinical and experimental immunology},
  year={2006},
  volume={145 2},
  pages={296-301}
}
Approximately 5% of people infected with human T lymphotropic virus type 1 (HTLV-1) develop clinical myelopathy or tropical spastic paraparesis (HAM/TSP) that is associated with high-levels of Th1 cytokines, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha. Chemokines are known to induce cytokine secretion and direct the trafficking of immune cells to sites of disease. The present study measured serum chemokines correlated with autonomously released IFN-gamma in cell cultures. HTLV… CONTINUE READING

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