Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.

@article{DuffieldLillico2009LevelsOP,
  title={Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.},
  author={Anna J. Duffield-Lillico and Jay O. Boyle and Xi Kathy Zhou and Aradhana Ghosh and Geera S Butala and Kotha Subbaramaiah and Robert A. Newman and Jason D. Morrow and Ginger L Milne and Andrew J. Dannenberg},
  journal={Cancer prevention research},
  year={2009},
  volume={2 4},
  pages={322-9}
}
Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) play a role in inflammation and carcinogenesis. Biomarkers that reflect tobacco smoke-induced tissue injury are needed. In this study, levels of urinary prostaglandin E metabolite (PGE-M) and leukotriene E(4) (LTE(4)), biomarkers of the COX and 5-LO pathways, were compared in never smokers, former smokers, and current smokers. The effects of celecoxib, a selective COX-2 inhibitor, on levels of PGE-M and LTE(4) were determined. Baseline levels… CONTINUE READING

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