Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.

Abstract

We have developed an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay for the measurement of Alzheimer's disease (AD) abnormally hyperphosphorylated tau in cerebrospinal fluid (CSF). The assay, which recognizes attomolar amounts of tau, is approximately 400 and approximately 1300 times more sensitive than conventional enzyme… (More)

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@article{Hu2002LevelsON, title={Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.}, author={Yuan Hu and Shan Shu He and Xiaochuan Wang and Qiu Hong Duan and Inge Grundke-Iqbal and Khalid Iqbal and Jianzhi Wang}, journal={The American journal of pathology}, year={2002}, volume={160 4}, pages={1269-78} }