Levels of mTOR and its downstream targets 4E‐BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

@article{Li2005LevelsOM,
  title={Levels of mTOR and its downstream targets 4E‐BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain},
  author={Xu Li and Irina Alafuzoff and Hilkka Soininen and Bengt Winblad and Jin-jing Pei},
  journal={The FEBS Journal},
  year={2005},
  volume={272}
}
The pathogenesis of formation of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brains is unknown. One of the possibilities might be that translation of tau mRNA is aberrantly regulated in AD brains. In the current study, levels of various translation control elements including total and phosphorylated (p) forms of mammalian target of rapamycin (mTOR), eukaryotic initiation factor 4E binding protein 1 (4E‐BP1), eukaryotic elongation factor 2 (eEF2), and eEF2 kinase were investigated… Expand
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