Levels of leptin during hydrocortisone infusions that mimic normal and reversed diurnal cortisol levels in subjects with adrenal insufficiency.

@article{Purnell1999LevelsOL,
  title={Levels of leptin during hydrocortisone infusions that mimic normal and reversed diurnal cortisol levels in subjects with adrenal insufficiency.},
  author={Jonathan Q Purnell and Mary Samuels},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 9},
  pages={
          3125-8
        }
}
Levels of leptin throughout the day follow a circadian pattern, with a trough in the late morning/early afternoon and a peak at midnight. This pattern of appearance of leptin correlates inversely with the circadian appearance of cortisol. Pharmacological doses of cortisol increase leptin messenger RNA expression in vitro and raise plasma leptin levels in animals and humans. To determine whether the circadian appearance of leptin might be accounted for by delayed effects from physiological… CONTINUE READING

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American journal of physiology. Endocrinology and metabolism • 2002
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