Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia.

@article{Musallam2011LevelsOG,
  title={Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia.},
  author={Khaled M. Musallam and Ali T Taher and Lorena Duca and C Cesaretti and Racha Halawi and Maria Domenica Cappellini},
  journal={Blood cells, molecules & diseases},
  year={2011},
  volume={47 4},
  pages={232-4}
}
Transfusion-independent patients with β thalassemia intermedia (TI) experience a variety of clinical complications attributed to the underlying ineffective erythropoiesis and subsequent anemia, hemolysis, and iron overload. Growth differentiation factor-15 (GDF-15) was recently investigated as a marker of ineffective erythropoiesis in several anemias. In this work, we evaluated GDF-15 levels in 55 patients with TI. The mean GDF-15 level was 25,197.8±16,208.9pg/ml which is lower than values… CONTINUE READING