Levels of endogenous adenosine in rat striatum. I. Regulation by ionotropic glutamate receptors, nitric oxide and free radicals.

@article{Delaney1998LevelsOE,
  title={Levels of endogenous adenosine in rat striatum. I. Regulation by ionotropic glutamate receptors, nitric oxide and free radicals.},
  author={Shannon M. Delaney and P Nicolas Shepel and Jonathan Geiger},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={285 2},
  pages={561-7}
}
Glutamate release after ischemia, hypoxia and seizure activity plays an important role in stimulating adenosine production and release. We characterized the ionotropic glutamate receptor subtype that regulates adenosine levels in vivo and investigated the role of nitric oxide and free radicals in mediating N-methyl-D-aspartate (NMDA)-induced increases in adenosine levels. Rats received unilateral intrastriatal injections and were sacrificed 15 min postinjection by high-energy focused microwave… CONTINUE READING

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The Rat in Stereotaxic Coordinates

  • G Paxinos, C Watson
  • 1986
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