Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers.

@article{Janoff1983LevelsOE,
  title={Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers.},
  author={Aaron Janoff and Leela Raju and R D Dearing},
  journal={The American review of respiratory disease},
  year={1983},
  volume={127 5},
  pages={
          540-4
        }
}
Elastase activity was measured in concentrated, cell-free bronchoalveolar lavage (BAL), using the synthetic substrate butyloxycarbonyl-L-alanyl-L-alanyl-L-prolyl-L-valyl-amino-methylcoumarin. The BAL fluids obtained from young, asymptomatic smokers with normal urine desmosine concentrations 1 h after they had smoked 2 cigarettes showed significant increases in elastase levels compared with those in nonsmoking control subjects [nanomoles substrate hydrolyzed (3 h) per milligram lavage albumin… CONTINUE READING

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