Levels of dopamine in blood and brain following nasal administration to rats.

@article{Dahlin2001LevelsOD,
  title={Levels of dopamine in blood and brain following nasal administration to rats.},
  author={Maria Dahlin and Bj{\"o}rn Jansson and E. A. Bj{\"o}rk},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2001},
  volume={14 1},
  pages={
          75-80
        }
}
The aim of this study was to investigate the levels of [(3)H]dopamine in blood, the cerebrospinal fluid (CSF) and brain tissue samples in rats and to find out whether the drug is transferred along the olfactory pathway to the central nervous system following nasal administration. [(3)H]Dopamine (50 microCi) was given to male Sprague-Dawley rats either intravenously or nasally to the right nostril. For the absorption study, blood samples were withdrawn from the carotid artery. The CSF samples… CONTINUE READING

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