Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study.

@article{Lammers2014LevelsOA,
  title={Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study.},
  author={Willem J. Lammers and Henk R van Buuren and Gideon M. Hirschfield and Harry L. A. Janssen and Pietro Invernizzi and Andrew L. Mason and Cyriel Y. Ponsioen and Annarosa Floreani and Christophe Corpechot and Marlyn J. Mayo and Pier Maria Battezzati and Albert Pares and Frederik Nevens and Andrew K. Burroughs and Kris V. Kowdley and P J Trivedi and Teru Kumagi and Angela C. Cheung and Ana Lleo and M. H. Toufiq Imam and Kirsten Boonstra and Nora Cazzagon and Irene Franceschet and Raoul Poupon and Llorenç Caballer{\'i}a and Giulia Pieri and Pushpjeet S Kanwar and Keith D Lindor and Bettina E Hansen},
  journal={Gastroenterology},
  year={2014},
  volume={147 6},
  pages={1338-49.e5; quiz e15}
}
BACKGROUND & AIMS Noninvasive surrogate end points of long-term outcomes of patients with primary biliary cirrhosis (PBC) are needed to monitor disease progression and evaluate potential treatments. We performed a meta-analysis of individual patient data from cohort studies to evaluate whether patients' levels of alkaline phosphatase and bilirubin correlate with their outcomes and can be used as surrogate end points. METHODS We performed a meta-analysis of data from 4845 patients included in… CONTINUE READING
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