Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis

@article{Viswanath2011LevelsOS,
  title={Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis},
  author={Vishad Viswanath and Arpita Myles and Rajesh Dayal and Amita Aggarwal},
  journal={The Journal of Rheumatology},
  year={2011},
  volume={38},
  pages={2482 - 2487}
}
Objective. Serum matrix metalloproteinase-3 (MMP-3) has been shown to reflect disease activity in ankylosing spondylitis (AS) and rheumatoid arthritis. Elevated levels have been found in juvenile idiopathic arthritis (JIA). In the enthesitis-related arthritis category of JIA (JIA-ERA), we studied whether serum MMP-3 levels and ratios of MMP-3/tissue inhibitor of metalloproteinase (TIMP-1) are correlated with disease activity and whether they are sensitive to change in disease activity. Methods… Expand
Changes of serum levels of MMP-3, sRANKL, and OPG in juvenile-onset ankylosing spondylitis patients carrying different HLA-B27 subtypes
TLDR
The significantly higher sRANKL expression suggested the enhanced osteoclast function and imbalance of RANKL/OPG system in the inflammatory process of JAS patients carrying different HLA-B27 subtypes. Expand
Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis
TLDR
This study suggested that serum levels of vitamin D were low in Moroccan children with JIA disease, and a larger population are needed to confirm the results. Expand
MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis.
TLDR
Monitoring serum levels of MMP3 reflects positively RA disease activity, joint and bone injury, and radiological erosion and predict disease outcome and drug responsiveness as summarized in several publications reporting outcomes on more than 8000 patients with RA. Expand
Patients with enthesitis related arthritis show similar monocyte function pattern as seen in adult axial spondyloarthropathy
TLDR
ERA patients have similar monocyte response to exogenous and endogenous TLR ligands as patients with axial SpA, which suggests that differences between pediatric and adult-onset SpA are minimal and they may have a common pathogenesis. Expand
Concerted Actions by PIICP, CTXII, and TNF-α in Patients with Juvenile Idiopathic Arthritis
TLDR
It is shown that 96 JIA patients have elevated levels of procollagen II C-terminal propeptide (PIICP), reflecting the extent of joint cartilage biosynthesis, and C-telopeptide of type II collagen (CTXII), a biomarker of the resorption of this tissue. Expand
Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls
TLDR
The role of MMPs increased in children with permanent dentition, whereas in reference to dental caries, the period of mixed dentition was critical, and despite a comparable clinical oral status of affected and unaffected children, in the JIA patients, a statistically significantly increased level of M MP-9 was found. Expand
Alterations of Extracellular Matrix Components in the Course of Juvenile Idiopathic Arthritis
TLDR
Enzymatic and non-enzymatic factors involved in catabolism of matrix components and molecules stimulating their biosynthesis are reviewed to provide the introduction of both new diagnostic tools and new therapeutic strategies in children with JIA. Expand
Bone Mineral Density in Moroccan Patients with Juvenile Idiopathic Arthritis
TLDR
This study suggests that osteopenia was a frequent complication in Moroccan patients with juvenile idiopathic arthritis and its correlates with disease parameters and vitamin D status, and there was no significant association in this study between the BMD and disease duration, daily intake of calcium, and 25-hydroxyvitamin D. Expand
Role of Biomarkers in Juvenile Idiopathic Arthritis
TLDR
To obtain the best clinical outcomes in JIA, it is important to understand the pathophysiology of each JIA subtype and to select and use appropriate biomarkers. Expand
Bone Mineral Density in Moroccan Patients with Juvenile Idiopathic
TLDR
Evaluating the bone mineral density in Moroccan patients with juvenile idiopathic arthritis suggested that osteopenia was a frequent complication of JIA and it was associated to systemic subtype of Jia, height and cumulative dose of corticosteroids. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 28 REFERENCES
Serum matrix metalloproteinase-3 as predictor of joint destruction in rheumatoid arthritis, treated with non-biological disease modifying anti-rheumatic drugs.
TLDR
MMP-3 can be a useful marker for prediction of joint destruction in rheumatoid arthritis treated with non-biological disease modifying anti-rheumatic drugs. Expand
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity.
TLDR
It is shown that MMP-3 is a more useful biomarker than ESR and CRP to detect high disease activity in ankylosing spondylitis. Expand
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
TLDR
MMP-1 is up-regulated in SF concordant with inflammatory activity in JIA, suggesting that the capability for degradation of type II collagen is present in early disease, and throughout the disease course. Expand
Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis.
TLDR
Baseline serum M MP-1 and MMP-3 levels correlate with disease activity and predict functional and radiographic outcome in early untreated RA, and may have a particular value in predicting the progression of erosive disease in patients who are not erosives at presentation. Expand
Serum and synovial fluid concentrations of matrix metalloproteinases 3 and its tissue inhibitor 1 in juvenile idiopathic arthritides.
TLDR
MMP-3 (stromelysin-1) is clearly overexpressed in SF of patients with JIA, and an inadequate counter-expression of TIMP-1 may represent a crucial event for the development and perpetuation of tissue damage. Expand
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis
TLDR
The authors' is the first study reporting elevated sRANKL and reduced OPG levels and elevated rANKL/OPG ratio in SF of children with JIA resulting in a mileu associated with bone loss which may partly explain lesser degree of joint damage seen in ERA as compared to poly JIA. Expand
Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis.
TLDR
Results indicate that MMP-3 is a significant independent predictor of radiographic progression in patients with AS, particularly in those with preexisting radiographic damage. Expand
Elevated serum receptor activator of NFκB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis
TLDR
This is the first study to show elevated RANKL in serum of patients with JIA, and association of the MMP3/TIMP-1 ratio with disease activity suggests that it may be a useful biomarker for follow-up. Expand
Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis.
TLDR
MMP-3 and M-CSF are potentially useful markers of ankylosing spondylitis disease activity, and Logistic regression analysis showed that M MP-3 values were high in those with severely active disease. Expand
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy.
TLDR
Serum MMP-3, originating from the inflamed joint, represents a valuable biomarker for peripheral synovitis and could contribute to the antiinflammatory and tissue-remodeling effects of TNFalpha blockade in SpA. Expand
...
1
2
3
...