Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.

@article{Roy2006LevelsOI,
  title={Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.},
  author={Deodutta Roy and Shubhashish Sarkar and Quentin Felty},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2006},
  volume={11},
  pages={
          889-98
        }
}
Different cellular signaling pathways operate in response to varying levels of IL-1 beta leading to genotoxic damage, cell apoptosis or cell growth. At high levels of IL-1 beta, cells receiving genotoxic insults engage apoptotic pathways. The IL-1 beta over expressing stable MCF7 cell secreting high level of IL-1 beta peptides undergo cell apoptosis. Cotreatment with an inhibitor of IL-1 beta and TNF-alpha synthesis prevented stilbene estrogen-induced lesions. In addition to direct effect of 17… Expand
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