Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.

@article{Roy2006LevelsOI,
  title={Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.},
  author={Deodutta Roy and Shubhashish Sarkar and Quentin Felty},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2006},
  volume={11},
  pages={
          889-98
        }
}
Different cellular signaling pathways operate in response to varying levels of IL-1 beta leading to genotoxic damage, cell apoptosis or cell growth. At high levels of IL-1 beta, cells receiving genotoxic insults engage apoptotic pathways. The IL-1 beta over expressing stable MCF7 cell secreting high level of IL-1 beta peptides undergo cell apoptosis. Cotreatment with an inhibitor of IL-1 beta and TNF-alpha synthesis prevented stilbene estrogen-induced lesions. In addition to direct effect of 17… 
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References

SHOWING 1-10 OF 105 REFERENCES
The influence of inflammatory cytokines on estrogen production and cell proliferation in human breast cancer cells.
TLDR
Results led to the hypothesis that inflammatory cytokines such as IL-6 and IL-1 beta regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue.
Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases.
TLDR
A significant role for interleukin-1 is demonstrated in implantation and growth of metastatic melanoma in the liver by specifically blocking IL-1 receptors using the naturally occurring IL- 1 receptor antagonist (IL-1Ra).
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
TLDR
The role of IL-1 beta is suggested as a cytokine inducing VEGF in cardiac myocytes, and activation of stress-activated MAP kinases regulate Sp1 sites-dependent transcription is implied.
Differential Effects of IL-1α and IL-1β on Tumorigenicity Patterns and Invasiveness 1
TLDR
IL-1α reduces tumorigenicity by inducing antitumor immunity, whereas IL-1β promotes invasiveness, including tumor angiogenesis, and also induces immune suppression in the host, this is, to the authors' knowledge, the first report on differential, nonredundant, in vivo effects of IL- 1α and IL-2β in malignant processes.
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
TLDR
A role for IL-1beta and IL-18 in the development of hepatic metastases of B16M in vivo is demonstrated and is demonstrated to be related to cancer cell adhesion and liver metastases.
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha.
TLDR
It is demonstrated that conditioned medium from estrogen receptor (ER)-negative but not ER-positive breast cancer cells induces NF-kappaB in fibroblasts, and the known role of IL-1alpha and IL-6 in osteoclast formation provides insight into the mechanism of metastasis and hypercalcemia in advanced breast cancers.
In vitro demonstration of breast cancer tumor cell sub-populations based on interleukin-1/tumor necrosis factor induction of interleukin-8 expression.
TLDR
In vitro data support the hypothesis, that within the HBC tumor microenvironment, tumor cells exist that respond to pro-inflammatory cytokine (IL-1) stimulation and further indicate that IL-1 is a potent inducer of IL-8 expression by BEC and BCC.
NF-κB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1α
TLDR
It is demonstrated that conditioned medium from estrogen receptor (ER)-negative but not ER-positive breast cancer cells induces NF-κB in fibroblasts, and the known role of IL-1α and IL-6 in osteoclast formation provides insight into the mechanism of metastasis and hypercalcemia in advanced breast cancers.
Transfection of Ovarian Cancer Cells with Tumor Necrosis Factor-α (TNF-α) Antisense mRNA Abolishes the Proliferative Response to Interleukin-1 (IL-1) but Not TNF-α
TLDR
Transfecting ovarian cancer cell line OVCA 432 with vectors that contain the TNF-alpha gene in the antisense or sense orientation shows a 4.5- to 26-fold reduction in IL-1-induced T NF-alpha secretion, which is consistent with a model in which the macrophage-derived cytokines IL- 1 and TNP-alpha might stimulate endogenous production of TNP that in turn could stimulate proliferation of ovarian cancer cells by autocrine growth regulation.
Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro.
TLDR
The ability to secrete IL-1 could increase the metastatic potential of melanoma cells by stimulating tumor cell-EC adhesion and blocking antibodies to endothelial vascular cell adhesion molecule 1, endothelial-leukocyte adhesion molecules 1, and ICAM-1 failed to inhibit melanoma- EC adhesion.
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