Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.

@article{Roy2006LevelsOI,
  title={Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.},
  author={Deodutta Roy and Shubhashish Sarkar and Quentin Felty},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2006},
  volume={11},
  pages={
          889-98
        }
}
Different cellular signaling pathways operate in response to varying levels of IL-1 beta leading to genotoxic damage, cell apoptosis or cell growth. At high levels of IL-1 beta, cells receiving genotoxic insults engage apoptotic pathways. The IL-1 beta over expressing stable MCF7 cell secreting high level of IL-1 beta peptides undergo cell apoptosis. Cotreatment with an inhibitor of IL-1 beta and TNF-alpha synthesis prevented stilbene estrogen-induced lesions. In addition to direct effect of 17… 

Figures from this paper

Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.
TLDR
Results indicate that macrophage-mediated induction of COX-2 in breast cancer cells is a consequence of IL-1β-mediated stimulation of ROS→Src→MAPK→AP-1 signaling, which provides a mechanism whereby macrophages contribute to tumor progression and potential therapeutic targets in Breast cancer.
NF-kappaB-dependent MicroRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction
TLDR
A critical role is shown for NF-kappaB-dependent upregulation of miR-425, which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1β induction.
Tumorigenicity of IL-1α– and IL-1β–Deficient Fibrosarcoma Cells
TLDR
In vivo growth of IL-1-deficient tumor lines was evaluated in nu/nu mice and was compared with in vitro growth characteristics, finding that stronger tumorigenicity ofIL-1βcomp lines grows more aggressively, efficiently induce angiogenesis, and recruit inflammatory cells.
High expression of IL-1β and NFκB in tumor tissue predicts a low recurrence rate of hepatocellular carcinoma.
TLDR
The low expressions of IL-1β and NFκB in HCC tissues are an independent risk factor for the recurrence of HCC after hepatectomy, but a high expression can significantly prolong DFS.
Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death
TLDR
The ablation of murine GABARAP, a member of the Atg8/LC3 family that is central to autophagosome formation, suppresses the incidence of tumor formation mediated by the carcinogen DMBA and results in an enhancement of the immune response through increased secretion of IL-1β,IL-6, IL-2 and IFN-γ from stimulated macrophages and lymphocytes.
...
...

References

SHOWING 1-10 OF 105 REFERENCES
The influence of inflammatory cytokines on estrogen production and cell proliferation in human breast cancer cells.
TLDR
Results led to the hypothesis that inflammatory cytokines such as IL-6 and IL-1 beta regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue.
Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases.
TLDR
A significant role for interleukin-1 is demonstrated in implantation and growth of metastatic melanoma in the liver by specifically blocking IL-1 receptors using the naturally occurring IL- 1 receptor antagonist (IL-1Ra).
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
TLDR
The role of IL-1 beta is suggested as a cytokine inducing VEGF in cardiac myocytes, and activation of stress-activated MAP kinases regulate Sp1 sites-dependent transcription is implied.
Differential Effects of IL-1α and IL-1β on Tumorigenicity Patterns and Invasiveness 1
TLDR
IL-1α reduces tumorigenicity by inducing antitumor immunity, whereas IL-1β promotes invasiveness, including tumor angiogenesis, and also induces immune suppression in the host, this is, to the authors' knowledge, the first report on differential, nonredundant, in vivo effects of IL- 1α and IL-2β in malignant processes.
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.
TLDR
A role for IL-1beta and IL-18 in the development of hepatic metastases of B16M in vivo is demonstrated and is demonstrated to be related to cancer cell adhesion and liver metastases.
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha.
TLDR
It is demonstrated that conditioned medium from estrogen receptor (ER)-negative but not ER-positive breast cancer cells induces NF-kappaB in fibroblasts, and the known role of IL-1alpha and IL-6 in osteoclast formation provides insight into the mechanism of metastasis and hypercalcemia in advanced breast cancers.
In vitro demonstration of breast cancer tumor cell sub-populations based on interleukin-1/tumor necrosis factor induction of interleukin-8 expression.
TLDR
In vitro data support the hypothesis, that within the HBC tumor microenvironment, tumor cells exist that respond to pro-inflammatory cytokine (IL-1) stimulation and further indicate that IL-1 is a potent inducer of IL-8 expression by BEC and BCC.
NF-κB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1α
TLDR
It is demonstrated that conditioned medium from estrogen receptor (ER)-negative but not ER-positive breast cancer cells induces NF-κB in fibroblasts, and the known role of IL-1α and IL-6 in osteoclast formation provides insight into the mechanism of metastasis and hypercalcemia in advanced breast cancers.
Transfection of Ovarian Cancer Cells with Tumor Necrosis Factor-α (TNF-α) Antisense mRNA Abolishes the Proliferative Response to Interleukin-1 (IL-1) but Not TNF-α
TLDR
Transfecting ovarian cancer cell line OVCA 432 with vectors that contain the TNF-alpha gene in the antisense or sense orientation shows a 4.5- to 26-fold reduction in IL-1-induced T NF-alpha secretion, which is consistent with a model in which the macrophage-derived cytokines IL- 1 and TNP-alpha might stimulate endogenous production of TNP that in turn could stimulate proliferation of ovarian cancer cells by autocrine growth regulation.
Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro.
TLDR
The ability to secrete IL-1 could increase the metastatic potential of melanoma cells by stimulating tumor cell-EC adhesion and blocking antibodies to endothelial vascular cell adhesion molecule 1, endothelial-leukocyte adhesion molecules 1, and ICAM-1 failed to inhibit melanoma- EC adhesion.
...
...