Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation.

@article{Chauhan2009LevelsOF,
  title={Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation.},
  author={Sunil K Chauhan and Daniel R. Saban and Hyung Keun Lee and Reza Dana},
  journal={Journal of immunology},
  year={2009},
  volume={182 1},
  pages={148-53}
}
Foxp3 expressing CD4(+)CD25(+) regulatory T cells (Tregs) have been shown to prevent allograft rejection in clinical and animal models of transplantation. However, the role of Foxp3 in regulating Treg function, and the kinetics and mechanism of action of Tregs in inducing allograft tolerance in transplantation, are still not fully understood. Thus, we investigated the kinetics and function of Tregs in a mouse model of orthotopic corneal transplantation, the most common form of tissue grafting… CONTINUE READING

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