Levels of CD40 expression on dendritic cells dictate tumour growth or regression.

@article{Murugaiyan2007LevelsOC,
  title={Levels of CD40 expression on dendritic cells dictate tumour growth or regression.},
  author={Gopal Murugaiyan and Sophie Martin and Bhaswati Saha},
  journal={Clinical and experimental immunology},
  year={2007},
  volume={149 1},
  pages={194-202}
}
Tumour regression requires activation of T cells. It has been shown that the interaction between T cell-expressed CD40-ligand (CD40-L) and antigen-presenting cell-expressed CD40 plays a crucial role in T cell activation. CD40-L- or CD40-deficient mice are susceptible to tumour growth. CD40-based therapies are also shown to control tumour growth significantly, suggesting that CD40-CD40-L interaction induces anti-tumour T cell responses and tumour regression. We demonstrate that the anti-tumour T… CONTINUE READING

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