Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.

@article{Bortel2001LevelsOA,
  title={Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.},
  author={Roman Bortel and Dianne Waite and Barbara J. Whalen and Diane M. Todd and Jean H. Leif and Elena Lesma and Jill Moss and John P Mordes and Aldo A. Rossini and Dale L. Greiner},
  journal={Autoimmunity},
  year={2001},
  volume={33 3},
  pages={
          199-211
        }
}
ART2a and ART2b are isoenzymes expressed on the surface of mature T cells and intraepithelial lymphocytes (IELs) in the rat. They exhibit both adenosine diphosphoribosyltransferase and nicotine adenine dinucleotide (NAD) glycohydrolase activities, and both can generate a transmembrane signal that modulates T cell activation. The presence or absence of ART2+ T cells modulates the expression of autoimmune diabetes in the BB rat. ART2 also circulates in a soluble form whose function is unknown. We… CONTINUE READING