Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine.

@article{Fitzmaurice2006LevelsO4,
  title={Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine.},
  author={Paul S. Fitzmaurice and Junchao Tong and Mehrdad Yazdanpanah and Peter Liu and Kathryn S. Kalasinsky and Stephen J. Kish},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={319 2},
  pages={703-9}
}
Animal studies suggest that the widely used psychostimulant drug methamphetamine (MA) can harm brain dopamine neurones, possibly by causing oxidative damage. However, evidence of oxidative damage in brain of human MA users is lacking. We tested the hypothesis that levels of two "gold standard" products generated from lipid peroxidation, 4-hydroxynonenal (one of the most reactive lipid peroxidation aldehyde products) and malondialdehyde, would be elevated in post mortem brain of 16 dopamine… CONTINUE READING

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