Level of receptor-associated protein moderates cellular susceptibility to pseudomonas exotoxin A.

@article{Mucci1995LevelOR,
  title={Level of receptor-associated protein moderates cellular susceptibility to pseudomonas exotoxin A.},
  author={Domenico Mucci and Judith J. Forristal and Dudley K Strickland and Robert Morris and David J P Fitzgerald and Catharine B. Saelinger},
  journal={Infection and immunity},
  year={1995},
  volume={63 8},
  pages={2912-8}
}
Pseudomonas exotoxin A (PE) enters mammalian cells via a receptor-mediated endocytic pathway. The initial step in this pathway is binding to the multiligand receptor termed the alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein (LRP). Binding of toxin, and of the many other ligands that bind to LRP, is blocked by the addition of a 39-kDa receptor-associated protein (RAP). Here we show that approximately 40% of the cell-associated LRP is on the surface of toxin… CONTINUE READING

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