Level of purposeful hand function as a marker of clinical severity in Rett syndrome.

@article{Downs2010LevelOP,
  title={Level of purposeful hand function as a marker of clinical severity in Rett syndrome.},
  author={Jenny Downs and Ami Bebbington and Peter J Jacoby and Anne-Marie Williams and Soumya Ghosh and Walter E. Kaufmann and Helen Paige Leonard},
  journal={Developmental medicine and child neurology},
  year={2010},
  volume={52 9},
  pages={817-23}
}
AIM We investigated relationships between hand function and genotype and aspects of phenotype in Rett syndrome. METHOD Video assessment in naturalistic settings was supplemented by parent-reported data in a cross-sectional study of 144 females with a mean age of 14 years 10 months (SD 7 y 10 mo; range 2 y-31 y 10 mo), 110 of whom had a mutation of the methyl CpG binding protein 2 (MECP2) gene. Ordinal logistic regression was used to assess relationships between hand function and MECP2… CONTINUE READING

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