Level of fetal hemoglobin as an indicator of clinical complications in sickle cell anemia.


1. The fetal hemoglobin (HbF) level was used as an indicator of the development of severe clinical complications in 89 patients with sickle cell anemia (SCA). 2. HbF was determined by the alkali denaturation technique. The mean HbF level was 6.7 +/- 4.2% (range, 0.7 to 19.2%) of total hemoglobin. 3. Major organ failures were considered to be terminal events… (More)


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