Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling.

@article{Daines2006LevelOE,
  title={Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling.},
  author={Michael O. Daines and Yasuhiro Tabata and Bradley A. Walker and Weiguo Chen and Manoj R. Warrier and Saswata Basu and Gurjit K. Khurana Hershey},
  journal={Journal of immunology},
  year={2006},
  volume={176 12},
  pages={7495-501}
}
IL-13, a critical cytokine for allergic inflammation, exerts its effects through a complex receptor system including IL-4Ralpha, IL-13Ralpha1, and IL-13Ralpha2. IL-4Ralpha and IL-13Ralpha1 form a heterodimeric signaling receptor for IL-13. In contrast, IL-13Ralpha2 binds IL-13 with high affinity but does not signal. IL-13Ralpha2 exists on the cell surface, intracellularly, and in soluble form, but no information is available regarding the relative distributions of IL-13Ralpha2 among these… CONTINUE READING

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