Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.

@article{Dorudi1995LevelOE,
  title={Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.},
  author={Sina Dorudi and Andrew M. Hanby and Richard Poulsom and Julian R Northover and Ian R. Hart},
  journal={British Journal of Cancer},
  year={1995},
  volume={71},
  pages={614 - 616}
}
A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients. 

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