Level of an advanced glycated end product is genetically determined: a study of normal twins.

@article{Leslie2003LevelOA,
  title={Level of an advanced glycated end product is genetically determined: a study of normal twins.},
  author={R David Leslie and Huriya Beyan and P. A. Sawtell and Bernard O Boehm and Tim D. Spector and Harold Snieder},
  journal={Diabetes},
  year={2003},
  volume={52 9},
  pages={2441-4}
}
Reducing sugars react with amino groups in proteins, lipids, and nucleic acids to produce advanced glycation end products (AGEs), including N(epsilon)-carboxymethyl lysine (CML), which have been implicated in oxidative stress and vascular damage. The aim of this study was to determine whether genetic factors influence serum CML levels in normal subjects. We performed a classical twin study of CML in healthy nondiabetic female twins, 39 monozygotic and 45 dizygotic pairs, aged 21-74 years. Serum… CONTINUE READING

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