Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.

@article{Grootjans2011LevelOA,
  title={Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion.},
  author={Joep Grootjans and Caroline M I M Hodin and Jacco-Juri de Haan and Joep Pm Derikx and Kasper M A Rouschop and Fons K C P Verheyen and Ronald M. van Dam and Cornelis H. C. Dejong and Wim A. Buurman and Kaatje Lenaerts},
  journal={Gastroenterology},
  year={2011},
  volume={140 2},
  pages={529-539.e3}
}
BACKGROUND & AIMS In the intestine, Paneth cells participate in the innate immune response. Their highly secretory function makes them susceptible to environmental conditions that cause endoplasmic reticulum (ER) stress. We investigated whether intestinal ischemia/reperfusion (I/R) induces ER stress, thereby activating the unfolded protein response (UPR), and whether excessive UPR activation affects Paneth cells. In addition, we investigated the consequences of Paneth cell compromise during… CONTINUE READING

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