Level of action of cathodal DC polarisation induced inhibition of the human motor cortex

  title={Level of action of cathodal DC polarisation induced inhibition of the human motor cortex},
  author={Michael A. Nitsche and Maren S. Nitsche and C. Klein and Frithjof Tergau and John C. Rothwell and Walter Paulus},
  journal={Clinical Neurophysiology},

The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex

Evaluated whether a long-lasting suppression of cortical excitability could be induced by prolonged cathodal tDCS, and the impact of brain-derived neurotrophic factor (BDNF) gene polymorphisms, on tDCS after-effects.

Transcranial direct current stimulation effects on I-wave activity in humans.

Recordings of corticospinal volleys evoked by single-pulse transcranial magnetic stimulation of the primary motor cortex before and after a 5-min period of anodal or cathodal tDCS deliver additional evidence that tDCS changes the excitability of cortical neurons.

Manipulation of phosphene thresholds by transcranial direct current stimulation in man

The results show that tDCS elicits a transient, reversible excitability alteration of the visual cortex, thus representing a promising tool for neuroplasticity research.

Brain transcranial direct current stimulation modulates motor excitability in mice

The feasibility of tDCS in mice suggests the potential applicability of this technique to assess the potential therapeutic options of brain polarization in animal models of neurological and neuropsychiatric diseases.

Non‐synaptic mechanisms underlie the after‐effects of cathodal transcutaneous direct current stimulation of the human brain

The findings demonstrate that the after‐effects of tDCS have a non‐synaptic mechanism of action based upon changes in neural membrane function and could arise from alterations in transmembrane proteins and from electrolysis‐related changes in [H+] induced by exposure to constant electric field.

Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence.

PURPOSE Transcranial direct current stimulation (tDCS) has been shown to modify the perception threshold of phosphenes elicited by transcranial magnetic stimulation (TMS). The current study was

Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitability

Findings are compatible with the idea that tDCS-induced aftereffects in the cortical motor system are limited to the stimulated hemisphere, and that tDCs not only affects corticospinal circuits involved in producing MEPs but also inhibitory interneurons mediating transcallosal inhibition from the contralateral hemisphere.

Polarity-Specific Cortical Effects of Transcranial Direct Current Stimulation in Primary Somatosensory Cortex of Healthy Humans

TDCS can be used to modulate the excitability of S1 in polarity-dependent manner, which can be assessed by PPS, and an interesting topic for further studies could be the investigation of direct correlations between sensory changes and excitability changes induced by tDCS.

Effects of transcranial direct current stimulation on the excitability of the leg motor cortex

It is suggested that it is more difficult to suppress the excitability of the leg motor cortex with cathodal tDCS than the hand area of the motor cortex.



Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability.

It is suggested that polarity-driven alterations of resting membrane potentials represent the crucial mechanisms of the DC-induced after-effects, leading to both an alteration of spontaneous discharge rates and to a change in NMDA-receptor activation.

Facilitation of Implicit Motor Learning by Weak Transcranial Direct Current Stimulation of the Primary Motor Cortex in the Human

It is shown that weak direct currents are capable of improving implicit motor learning in the human and that the primary motor cortex is involved in the acquisition and early consolidation phase of implicit motorlearning.

Comparison of activation of corticospinal neurons and spinal motor neurons by magnetic and electrical transcranial stimulation in the lumbosacral cord of the anaesthetized monkey.

The different sites of activation of corticospinal neurons by TMS and TES, as well as the different distribution of D and I responses that they evoke, may both contribute to the differences in the onset latencies of the EMG responses evoked by these methods in human subjects.

Regional modulation of BOLD MRI responses to human sensorimotor activation by transcranial direct current stimulation

Findings support the view that reduced neuroaxonal excitability after cathodal tDCS causes reduced brain activity, but rather than affecting the primary sensorimotor input of an active task, the process appears to dampen those responses that rely on cortico‐cortical connections and related processing.

Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans

The authors show that in the human transcranial direct current stimulation is able to induce sustained cortical excitability elevations, and this technique is a potentially valuable tool in neuroplasticity modulation.

Polarization of the human motor cortex through the scalp

It is concluded that such weak (< 0.5 mA) anodal scalp DC, alternated with a cathodal DC, significantly depresses the excitability of the human motor cortex, providing evidence that a small electric field crosses the skull and influences the brain.

External modulation of visual perception in humans

The results show that primary visual functions, such as contrast detection can be transiently altered by transcranial weak direct current stimulation, most probably modulating neural excitability, as has been shown in the motor cortex previously.

Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine

The threshold for excitability of occipital cortex is lower in MwA patients compared with C, a direct neurophysiologic correlate for clinical observations that have indicated hyperexcitability of the occipITAL cortex in migraineurs.

Polarizing currents increase noradrenaline-elicited accumulation of cyclic AMP in rat cerebral cortex