Levamisole inhibits intestinal Cl- secretion via basolateral K+ channel blockade.

  title={Levamisole inhibits intestinal Cl- secretion via basolateral K+ channel blockade.},
  author={Edward C. Mun and Julio M. Mayol and Martin F. Riegler and Timothy C. O'Brien and Omid C Farokhzad and Jaekyung Cecilia Song and Charalabos Pothoulakis and Bruce J Hrnjez and Jeffrey B. Matthews},
  volume={114 6},
BACKGROUND & AIMS Phenylimidazothiazoles have recently been shown to activate wild-type and mutant cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in transfected cells and were proposed as therapy for cystic fibrosis. The aim of this study was to investigate the effects of phenylimidazothiazoles on regulated transepithelial Cl- transport in intact epithelia. METHODS T84 intestinal epithelial cells grown on permeable supports and stripped human colonic mucosal sheets… CONTINUE READING
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