Levamisole causes differential cytokine expression by elicited mouse peritoneal macrophages.

@article{Kimball1992LevamisoleCD,
  title={Levamisole causes differential cytokine expression by elicited mouse peritoneal macrophages.},
  author={Edward S. Kimball and C. R. Schneider and Melanie C Fisher and Matthew C. Clark},
  journal={Journal of leukocyte biology},
  year={1992},
  volume={52 3},
  pages={349-56}
}
Thioglycolate-elicited peritoneal macrophages from normal C57B1/6J mice were examined in vitro for bacterial lipopolysaccharide (LPS)-stimulated interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF) production. Macrophages from mice administered a single oral dose of levamisole (3 mg/kg) 1 to 4 days prior to macrophage harvest demonstrated a twofold enhancement of IL-1 production compared to vehicle-treated mice. In contrast, IL-6 production and TNF production by the same macrophages were… CONTINUE READING

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