Leupaxin is a novel LIM domain protein that forms a complex with PYK2.

@article{Lipsky1998LeupaxinIA,
  title={Leupaxin is a novel LIM domain protein that forms a complex with PYK2.},
  author={Brian P. Lipsky and Chan R. Beals and Donald E. Staunton},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 19},
  pages={
          11709-13
        }
}
We have identified a novel cytoplasmic protein, leupaxin, that is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. Leupaxin possesses two types of protein interaction domains. There are four carboxyl-terminal LIM domains in leupaxin that share 70% amino acid identity and 80% similarity with those in paxillin. Paxillin LIM domains mediate localization to focal contacts. In the amino-terminal region of leupaxin there are three short… CONTINUE READING

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Leupaxin binds to PEST domain tyrosine phosphatase PEP

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Leupaxin Promotes Bladder Cancer Proliferation, Metastasis, and Angiogenesis Through the PI3K/AKT Pathway.

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