Leukotrienes produced in allergic lung inflammation activate alveolar macrophages.

  title={Leukotrienes produced in allergic lung inflammation activate alveolar macrophages.},
  author={Reinaldo Correia Silva and Maristella A Landgraf and Meire Ioshie Hiyane and {\'A}lvaro Pacheco-Silva and Niels O. S. C{\^a}mara and Richardt G Landgraf},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={26 3},
It has been well-documented that leukotrienes (LTs) are released in allergic lung inflammation and that they participate in the physiopathology of asthma. A role for LTs in innate immunity has recently emerged: Cys-LTs were shown to enhance FcgammaR-mediated phagocytosis by alveolar macrophages (AMs). Thus, using a rat model of asthma, we evaluated FcgammaR-mediated phagocytosis and killing of Klebsiella pneumoniae by AMs. The effect of treatment with a cys-LT antagonist (montelukast) on… CONTINUE READING