Leukotrienes potentiate the effects of epinephrine and thrombin on human platelet aggregation.

@article{Mehta1986LeukotrienesPT,
  title={Leukotrienes potentiate the effects of epinephrine and thrombin on human platelet aggregation.},
  author={P. Mehta and J. Mehta and D. Lawson and I. Krop and L. Letts},
  journal={Thrombosis research},
  year={1986},
  volume={41 5},
  pages={
          731-8
        }
}
  • P. Mehta, J. Mehta, +2 authors L. Letts
  • Published 1986
  • Chemistry, Medicine
  • Thrombosis research
  • A cooperation between leukocytes and platelets relative to metabolism of arachidonic acid has been observed in animal studies. To determine potential stimulatory effects of leukotrienes (LTs) on human platelets, LTs were incubated with platelet rich plasma followed by addition of subthreshold concentration of aggregatory stimulus. LTs (LTE4 LTD4 LTC4) alone had no direct effect on platelet aggregation, but potentiated the effects of subthreshold concentrations of epinephrine and thrombin and… CONTINUE READING
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