Leukotrienes as mediators of airway obstruction.

  title={Leukotrienes as mediators of airway obstruction.},
  author={Jeffrey M Drazen},
  journal={American journal of respiratory and critical care medicine},
  volume={158 5 Pt 3},
  • Jeffrey M Drazen
  • Published 1998 in
    American journal of respiratory and critical care…
The cysteinyl leukotrienes are potent mediators of airway narrowing derived from the lipoxygenation of arachidonic acid and the adduction of glutathione to this eicosanoid backbone. In lower animals and humans, the cysteinyl leukotrienes are among the most potent airway contractile substances ever identified. Furthermore, these moieties can be recovered from the urine during induced or spontaneous asthma attacks. Most important, inhibition of the synthesis of the leukotrienes or prevention of… CONTINUE READING

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