Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.

@article{Samuelsson1987LeukotrienesAL,
  title={Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.},
  author={Bengt Samuelsson and Sven Erik K Dahl{\'e}n and Jan Ake Lindgren and Carol A. Rouzer and Charles N Serhan},
  journal={Science},
  year={1987},
  volume={237 4819},
  pages={1171-6}
}
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium ionophores) and converted to leukotrienes by a 5-lipoxygenase that also has leukotriene A4 synthetase activity. Leukotriene A4, an unstable epoxide, is hydrolyzed to leukotriene B4 or conjugated with glutathione to yield leukotriene C4 and its metabolites, leukotriene D4 and leukotriene E4. The leukotrienes participate in host defense reactions and pathophysiological… CONTINUE READING
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