Leukotrienes and atherosclerosis.

  title={Leukotrienes and atherosclerosis.},
  author={Graziano Riccioni and Magnus B{\"a}ck and Val{\'e}rie Capra},
  journal={Current drug targets},
  volume={11 7},
Evidence from experimental and genetic studies suggest the existence of a potential link between the leukotrienes (LT) signalling cascade, and the pathogenesis/progression of atherosclerosis and its serious consequences such as acute myocardial infarction (AMI), stroke, aortic aneurysms, and intimal hyperplasia. LT biosynthetic enzymes are expressed within atherosclerotic lesion, leading to production of cysteinyl-leukotrienes (Cys-LTs) and LTB4 that exert potent pro-inflammatory action through… CONTINUE READING


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