Leukotriene receptor antagonist attenuated airway inflammation and hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation model.

@article{Ujino2017LeukotrieneRA,
  title={Leukotriene receptor antagonist attenuated airway inflammation and hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation model.},
  author={Mariko Ujino and Naoya Sugimoto and Yuta Koizumi and Shoki Ro and Yasuhiro Kojima and Kamiyama-Hara Asae and N Yamashita and Ken Ohta and Hiroyuki Nagase},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  year={2017},
  volume={66S},
  pages={S21-S26}
}
BACKGROUND Viral infections are the most common triggers of asthma exacerbation, but the key molecules involved in this process have not been fully identified. Although cysteinyl leukotrienes (cysLTs) have been postulated as the key mediators, their precise roles remain largely unclear. To investigate the roles of cysLTs in virus-induced asthma exacerbation, we developed a murine model using a viral double-stranded RNA analog, polyinosinic-polycytidylic acid (poly I:C), and analyzed the effect… CONTINUE READING
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