Leukotriene E4 and granulocytic infiltration into asthmatic airways.

  title={Leukotriene E4 and granulocytic infiltration into asthmatic airways.},
  author={Lauri A. Laitinen and Annika Laitinen and Tari Haahtela and Vesa Vilkka and Bernd W Spur and Tak Hong Lee},
  volume={341 8851},
Sulphidopeptide leukotrienes are potent bronchoconstrictors and increase bronchial hyperreactivity, one of the hallmarks of asthma. We have demonstrated that leukotriene LTE4, the most stable of the sulphidopeptide leukotrienes, elicited an increase in the numbers of eosinophils and neutrophils in the lamina propria of the airway mucosa 4 h after inhalation in 4 asthmatic subjects. The numbers of eosinophils were, on average, 10-fold greater than those of neutrophils. There was no significant… CONTINUE READING