Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value.

  title={Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value.},
  author={Zheng Zhu and Yan-qing Xie and Wei-Jie Guan and Y Gao and Shu Xia and Jianxin Liang and Jinping Zheng},
  journal={Experimental and therapeutic medicine},
  volume={12 1},
Cysteinyl leukotrienes (LT) play a vital role in the pathogenesis of allergic rhinitis (AR), but few studies have investigated the nasal mucosal physiological response to LTs in AR patients. The aim of the present study was to establish the methodology and investigate the diagnostic value and safety of a leukotriene D4 (LTD4) nasal provocation test. LTD4 nasal provocation tests were performed in 26 AR patients and 16 normal control subjects. Nasal airway responsiveness was assessed by… 
Effects of leukotriene D4 nasal challenge on bronchial responsiveness and inflammation in asthmatic patients with allergic rhinitis.
Although most asthmatic patients with AR were sensitive to LTD4 nasal challenge, LTD4 nose provocation tests do not confer any major effect on BHR, suggesting LTD4 might not play a vital role in eliciting bronchial responsiveness induced by nasal allergen challenge.


Leukotriene D4 bronchial provocation test: methodology and diagnostic value
The established procedure of LTD4 bronchial provocation test is effective in the diagnosis of asthma and is well tolerated, and future studies are necessary to provide more evidences in terms of safety and efficacy.
Leukotriene C4 and histamine in early allergic reaction in the nose
The measurements of LTC4 and histamine in nasal lavage fluids and blown secretions as a possible model of the early mediator events during nasal allergy showed a significantly higher concentration than in the pre‐ or post‐challenge lavage samples, compatible with transitory release during the acute allergic reaction.
Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans
LTD4 may play a role in nasal allergy by increasing blood flow and nasal airway resistance and can be accounted for by the release of histamine or other mediators.
Ratio of Leukotriene E4 to Exhaled Nitric Oxide and the Therapeutic Response in Children With Exercise-Induced Bronchoconstriction
The data indicate that the efficacy of montelukast for preventing a maximum decrease in FEV1 after exercise is significantly higher than that of FP, and the high LTE4/FENO ratio is associated with a greater response to montelUKast than to FP for EIB therapy.
The role of leukotrienes in asthma and allergic rhinitis
  • W. Busse
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1996
Results indicate that antileukotriene agents offer incremental improvements in airway caliber and may also attenuate the inflammatory response, and may have efficacy in other inflammation-associated disorders such as allergic rhinitis as well.
Leukotriene E4: perspective on the forgotten mediator.
Efficacy of montelukast for treating perennial allergic rhinitis.
In pooled data, montelukast consistently improved DNSS versus placebo during all 6 weeks of treatment, supportive of an overall benefit in PAR.
Nasal and bronchial inflammation after nasal allergen challenge: assessment using noninvasive methods.
Nasal allergen challenge induces clinical and inflammatory responses in the nose and bronchi that can be assessed using noninvasive methods such as nasal lavage, EBC, and nNO.