Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value.

@article{Zhu2016LeukotrieneDN,
  title={Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value.},
  author={Zheng Zhu and Yan-qing Xie and Wei-Jie Guan and Y Gao and Shu Xia and Jianxin Liang and Jinping Zheng},
  journal={Experimental and therapeutic medicine},
  year={2016},
  volume={12 1},
  pages={
          525-529
        }
}
Cysteinyl leukotrienes (LT) play a vital role in the pathogenesis of allergic rhinitis (AR), but few studies have investigated the nasal mucosal physiological response to LTs in AR patients. The aim of the present study was to establish the methodology and investigate the diagnostic value and safety of a leukotriene D4 (LTD4) nasal provocation test. LTD4 nasal provocation tests were performed in 26 AR patients and 16 normal control subjects. Nasal airway responsiveness was assessed by… 
Effects of leukotriene D4 nasal challenge on bronchial responsiveness and inflammation in asthmatic patients with allergic rhinitis.
TLDR
Although most asthmatic patients with AR were sensitive to LTD4 nasal challenge, LTD4 nose provocation tests do not confer any major effect on BHR, suggesting LTD4 might not play a vital role in eliciting bronchial responsiveness induced by nasal allergen challenge.

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