Leukotriene D4 acts in part to contract guinea pig ileum smooth muscle by releasing substance P.

@article{Bloomquist1987LeukotrieneDA,
  title={Leukotriene D4 acts in part to contract guinea pig ileum smooth muscle by releasing substance P.},
  author={Eunice Bloomquist and Richard M. Kream},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={240 2},
  pages={523-8}
}
The role of neurotransmitter release in generation of the contractile response to leukotriene D4 (LTD4) by guinea pig ileum longitudinal smooth muscle preparations was studied. The contractile response to LTD4 was inhibited partially by tetrodotoxin (TTx) with early portions of the contraction being more sensitive to inhibition by TTx. This finding suggests that part of the LTD4 contraction is mediated by release of a neurotransmitter as a result of activation of Na+-dependent action potentials… CONTINUE READING

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