Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology.

@article{Liu2020LeukotrieneDP,
  title={Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology.},
  author={Tao Liu and Nora A. Barrett and Jun Nagai and Juying Lai and Chunli Feng and Joshua A. Boyce},
  journal={The Journal of allergy and clinical immunology},
  year={2020}
}
BACKGROUND The three cysteinyl leukotrienes (cysLTs), (LT)C4, LTD4, and LTE4, have different biological half-lives, cellular targets, and receptor specificities. CysLT2R binds LTC4 and LTD4 in vitro with similar affinities, but displays a marked selectivity for LTC4 in vivo. LTC4, but not LTD4, strongly potentiates allergen-induced pulmonary eosinophilia in mice through a CysLT2R-mediated, platelet- and interleukin-33 dependent pathway. OBJECTIVE We sought to determine whether LTD4… Expand
1 Citations
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References

SHOWING 1-10 OF 63 REFERENCES
Cutting Edge: Leukotriene C4 Activates Mouse Platelets in Plasma Exclusively through the Type 2 Cysteinyl Leukotriene Receptor
TLDR
CysLT2R on platelets recognizes LTC4 with unexpected selectivity, and may activate platelets at a synapse with granulocytes before it is converted to LTD4, promoting mediator generation and the formation of leukocyte–platelet complexes that facilitate inflammation. Expand
Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor
TLDR
The adenosine diphosphate–reactive purinergic (P2Y12) receptor is required for proinflammatory actions of the stable abundant mediator LTE4 and is a novel potential therapeutic target for asthma. Expand
Cysteinyl Leukotriene Receptor 2 Drives Lung Immunopathology Through a Platelet and High Mobility Box 1-Dependent Mechanism
TLDR
It is demonstrated that platelets, activated through the type 2 cysLT receptor (CysLT2R), cause IL-33-dependent immunopathology through a rapidly inducible mechanism requiring the actions of high mobility box 1 (HMGB1) and the receptor for advanced glycation end products (RAGE). Expand
Platelet-Driven Leukotriene C4–Mediated Airway Inflammation in Mice Is Aspirin-Sensitive and Depends on T Prostanoid Receptors
TLDR
The autocrine and paracrine functions of thromboxane A2 act downstream of LTC4/type 2 cysLT receptor signaling on platelets to markedly amplify eosinophil recruitment through pulmonary vascular adhesion pathways, suggesting applications for TP receptor antagonists in cases of asthma with high levels of cys LT production. Expand
Characterization of the human cysteinyl leukotriene CysLT1 receptor
TLDR
The molecular and pharmacological characterization of the cloned human CysLT1 receptor is reported and the functional activation (calcium mobilization) of this receptor is described by LTD4 and LTC4, and competition for radiolabelled LTD4 binding to this receptor by the cysteinyl leukotrienes and three structurally distinct classes of Cys LT1-receptor antagonists. Expand
Characterization of the Human Cysteinyl Leukotriene 2 Receptor*
  • C. Heise, B. O'dowd, +20 authors Jilly F. Evans
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000
TLDR
The cloning and characterization of the second cysteinyl leukotriene receptor, CysLT2, a 346-amino acid protein with 38% amino acid identity to the Cys LT1 receptor is described and demonstrated high affinity binding and a rank order of potency for competition of LTC4 = LTD4 ≫ LTE4. Expand
Pharmacology of leukotriene receptor antagonists
  • Aharony
  • Medicine
  • American journal of respiratory and critical care medicine
  • 1998
TLDR
The preclinical profile suggests that cysLT1 receptor antagonists may be useful in treating inflammatory conditions of the respiratory system, such as asthma and allergic rhinitis. Expand
Type 2 Cysteinyl Leukotriene Receptors Drive IL-33–Dependent Type 2 Immunopathology and Aspirin Sensitivity
TLDR
It is demonstrated that the type 2 cysLT receptor (CysLT2R), which is not targeted by available drugs, is required in two different models to amplify eosinophilic airway inflammation via induced expression of IL-33 by lung epithelial cells. Expand
Cysteinyl Leukotriene 2 Receptor on Dendritic Cells Negatively Regulates Ligand-Dependent Allergic Pulmonary Inflammation
TLDR
CysLT2R negatively regulates the development of cys-LT–dependent Th2 pulmonary inflammation by inhibiting both CysLT1R signaling and D. farinae-induced LTC4S-dependent cell surface expression of Cys LT1R on DCs. Expand
Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.
TLDR
Data show that cysLT2-R activation results in a proinflammatory EC phenotype, and because LTD4 and thrombin are likely to be formed concomitantly in vivo, cys LT1-R and PAR-1 may cooperate to augment vascular injury. Expand
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