Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology.

  title={Leukotriene D4 Paradoxically Limits LTC4 Driven Platelet Activation and Lung Immunopathology.},
  author={Tao Liu and Nora A. Barrett and Jun Nagai and Juying Lai and Chunli Feng and Joshua A. Boyce},
  journal={The Journal of allergy and clinical immunology},
BACKGROUND The three cysteinyl leukotrienes (cysLTs), (LT)C4, LTD4, and LTE4, have different biological half-lives, cellular targets, and receptor specificities. CysLT2R binds LTC4 and LTD4 in vitro with similar affinities, but displays a marked selectivity for LTC4 in vivo. LTC4, but not LTD4, strongly potentiates allergen-induced pulmonary eosinophilia in mice through a CysLT2R-mediated, platelet- and interleukin-33 dependent pathway. OBJECTIVE We sought to determine whether LTD4… Expand
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  • The Journal of Biological Chemistry
  • 2000
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