Leukotriene C4 production by murine mast cells: evidence of a role for extracellular leukotriene A4.

@article{Dahinden1985LeukotrieneCP,
  title={Leukotriene C4 production by murine mast cells: evidence of a role for extracellular leukotriene A4.},
  author={Clemens Andreas Dahinden and Robert M. Clancy and Martin Gro\ss and Jacques M. Chiller and Tony E. Hugli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 19},
  pages={6632-6}
}
The glutathione-containing leukotriene C4 (LTC4) is a major mediator of smooth muscle contraction and is released by mast cells when antigen interacts with cell-bound IgE. Antigen-stimulated mast cells undergo phospholipase activation. We report a pathway of LTC4 production by mast cells that does not require phospholipase activation but depends on the interaction of activated neutrophils with unstimulated mast cells, using as an intermediate extracellular leukotriene A4 (LTA4). The epoxide… CONTINUE READING

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